Article
Apolipoprotein E and intronic polymorphism of presenilin 1 and alpha-1-antichymotrypsin in Alzheimer's disease and vascular dementia.
Dementia and geriatric cognitive disorders - 1 Jan 2000
Rodriguez Martin T, Calella A M, Silva S, Munna E, Modena P, Chiesa R, Terrevazzi S, Ruggieri R M, Palermo R, Piccoli F, Confalonieri R, Tiraboschi P, Fragiacomo C, Quadri P, Lucca U, Forloni G
Abstract excerpt
Apolipoprotein E (ApoE) genotypes, presenilin 1 (PS-1) and alpha(1)-antichymotrypsin (ACT) polymorphism and the association of the genotypes were examined in patients with Alzheimer's disease (AD, n = 121) or vascular dementia (VD, n = 68) in comparison with elderly controls (n = 125). The frequency of the ApoE epsilon 4 allele was significantly increased both in late-onset AD (0.35) and in VD (0.17); the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.