Article
A polymorphism in the tau gene associated with risk for Alzheimer's disease.
Neuroscience letters - 7 Jan 2000
Bullido M J, Aldudo J, Frank A, Coria F, Avila J, Valdivieso F
Abstract excerpt
Searching for tau genetic variations which could be associated with risk for Alzheimer's disease (AD), we have performed a mutational analysis of a region containing the whole exon 11 of the tau gene, which encodes a microtubule binding region critical for tau self-assembly, and we have found a biallelic polymorphism at position +34 of intron 11 (IVS11 + 34G/A). We have analyzed the allelic frequencies of this...
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