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Article

Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease.

Human genetics - 1 Apr 2002

Wang Xiaoyan, DeKosky Steven T, Luedecking-Zimmer Erin, Ganguli Mary, Kamboh M Ilyas

Abstract excerpt

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by extracellular neuritic plaques and intracellular neurofibrillary tangles in brain parenchyma. Alpha-1-antichymotrypsin (ACT) is a component of plaque cores, can bind to Abeta, and has been proposed as a possible candidate gene for AD susceptibility. The genetic association between the ACT codon -17*A allele of the signal peptide...

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Identifiers

PMID: 11941486
DOI: 10.1007/s00439-002-0697-3

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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