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Article

Genetic and structural analysis of G protein alpha subunit regulatory domains.

Journal of cellular biochemistry - 1 Oct 1991

Johnson G L, Dhanasekaran N, Gupta S K, Lowndes J M, Vaillancourt R R, Ruoho A E

Abstract excerpt

Genetic and structural analysis of the alpha chain polypeptides of heterotrimeric G proteins defines functional domains for GTP/GDP binding, GTPase activity, effector activation, receptor contact and beta gamma subunit complex regulation. The conservation in sequence comprising the GDP/GTP binding and GTPase domains among G protein alpha subunits readily allows common mutations to be made for the design of mutant...

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Identifiers

PMID: 1661737
DOI: 10.1002/jcb.240470207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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