Article
Genetic and structural analysis of G protein alpha subunit regulatory domains.
Journal of cellular biochemistry - 1 Oct 1991
Johnson G L, Dhanasekaran N, Gupta S K, Lowndes J M, Vaillancourt R R, Ruoho A E
Abstract excerpt
Genetic and structural analysis of the alpha chain polypeptides of heterotrimeric G proteins defines functional domains for GTP/GDP binding, GTPase activity, effector activation, receptor contact and beta gamma subunit complex regulation. The conservation in sequence comprising the GDP/GTP binding and GTPase domains among G protein alpha subunits readily allows common mutations to be made for the design of mutant...
Topics
- Adenosine Diphosphate Ribose
- Amino Acid Sequence
- Cyclic AMP
- GTP-Binding Proteins
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Recombinant Fusion Proteins
- Regulatory Sequences, Nucleic Acid