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Article

Mechanism of Galpha i-mediated inhibition of type V adenylyl cyclase.

The Journal of biological chemistry - 9 Aug 2002

Dessauer Carmen W, Chen-Goodspeed Misty, Chen Jun

Abstract excerpt

The topology of mammalian adenylyl cyclase reveals an integral membrane protein composed of an alternating series of membrane and cytoplasmic domains (C1 and C2). The stimulatory G protein, Galpha(s), binds within a cleft in the C2 domain of adenylyl cyclase while Galpha(i) binds within the opposite cleft in the C1 domain. The mechanism of these two regulators also appears to be in opposition. Activation of...

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Identifiers

PMID: 12058044
DOI: 10.1074/jbc.M203962200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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