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Article

Conversion of a guanylyl cyclase to an adenylyl cyclase.

Methods (San Diego, Calif.) - 1 Dec 1999

Beuve A

Abstract excerpt

Guanylyl cyclases catalyze the formation of cGMP from GTP, but display extensive identity at the catalytic domain primary amino acid level with the adenylyl cyclases. The recent solving of the crystal structures of soluble forms of adenylyl cyclase has resulted in predictions of those amino acids important for substrate specificity. Modeling of a membrane-bound homodimeric guanylyl cyclase predicted the...

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Identifiers

PMID: 10581153
DOI: 10.1006/meth.1999.0896

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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