Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype.

doi:10.1097/00008571-200007000-00008

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Article

Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype.

Pharmacogenetics - 1 Jul 2000

Brophy V H, Jarvik G P, Richter R J, Rozek L S, Schellenberg G D, Furlong C E

Abstract excerpt

Paraoxonase (PON1) is tightly associated with high-density lipoprotein particles and is believed to contribute to the prevention of atherosclerosis by metabolizing oxidized lipids. PON1 also hydrolyses the bioactive oxon forms of organophosphorus pesticides such as parathion, diazinon and chlorpyrifos. Two common polymorphisms have been identified in the coding sequence of human PON1: L55M and R192Q. Several...

Topics

Aged
Aged, 80 and over
Amino Acid Substitution
Aryldialkylphosphatase
Enzyme Activation
Esterases
Female
Genetic Carrier Screening
Genotype
Humans
Leucine
Male
Methionine
Middle Aged
Phenotype
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 10898114
DOI: 10.1097/00008571-200007000-00008

Genes

PON1

Variants

Provenance

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