Article
A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 1998
Moralejo D H, Ogino T, Zhu M, Toide K, Wei S, Wei K, Yamada T, Mizuno A, Matsumoto K, Shima K
Abstract excerpt
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, non-insulin-dependent diabetes mellitus (NIDDM) in humans. The OLETF rat has poor capacity for pancreatic proliferation, which may be the critical pathogenetic event in NIDDM development. Our investigation was de...
Topics
- Animals
- Cell Division
- Chromosome Mapping
- Diabetes Mellitus, Type 2
- Female
- Genetic Linkage
- Genotype
- Islets of Langerhans
- Male
- Pancreatectomy
- Phenotype
- Quantitative Trait, Heritable
- Rats
- Rats, Inbred F344