Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat.

doi:10.1007/s00335-010-9285-3

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Article

Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2010

Finlay Clare, Argoud Karène, Wilder Steven P, Ouali Fetta, Ktorza Alain, Kaisaki Pamela J, Gauguier Dominique

Abstract excerpt

Insulin resistance and altered endocrine pancreas function are central pathophysiological features of type 2 diabetes mellitus (T2DM). The Goto-Kakizaki (GK) rat is a model of spontaneous T2DM characterised by reduced beta cell mass and genetically determined glucose intolerance and altered insulin secretion. To identify genetic determinants of endocrine pancreas histopathology, we carried out quantitative trait...

Topics

Animals
Blood Glucose
Chromosome Mapping
Corticosterone
Crosses, Genetic
Diabetes Mellitus, Type 2
Disease Models, Animal
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Growth Hormone

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin

Insulin-Secreting Cells

Islets of Langerhans

Male

Pancreas

Phenotype

Source

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Identifiers

PMID: 20878524
DOI: 10.1007/s00335-010-9285-3
PMCID: PMC2974204

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