Article
Changes in islet capillary angioarchitecture coincide with impaired B-cell function but not with insulin resistance in male Otsuka-Long-Evans-Tokushima fatty rats: dimorphism of the diabetic phenotype at an advanced age.
Metabolism: clinical and experimental - 1 Apr 1999
Mizuno A, Noma Y, Kuwajima M, Murakami T, Zhu M, Shima K
Abstract excerpt
The Otsuka-Long-Evans-Tokushima fatty (OLETF) rat is a genetic model of spontaneous development of non-insulin-dependent diabetes mellitus (NIDDM) established as an inbred strain after 20 generations of selective breeding. Although they are thought to be genetically homogeneous, they show a dimorphism regarding the diabetic phenotype at an advanced age, with one remaining obese and modestly diabetic while the...
Topics
- Aging
- Animals
- Blood Glucose
- Body Weight
- Capillaries
- Diabetes Mellitus, Type 2
- Glucose
- Glucose Clamp Technique
- Glucose Tolerance Test
- Insulin Resistance