Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene.

The American journal of physiology - 1 Feb 1998

Takiguchi S, Takata Y, Takahashi N, Kataoka K, Hirashima T, Kawano K, Miyasaka K, Funakoshi A, Kono A

Abstract excerpt

Otsuka Long-Evans Tokushima fatty (OLETF) rats develop hyperglycemia, hyperinsulinemia, and mild obesity, which are characteristic of human non-insulin-dependent diabetes mellitus. We have shown that two recessive genes, ODB1 mapped on the X chromosome and ODB2 mapped on chromosome 14, are involved in the induction of the diabetes in OLETF rats. Recently we found that OLETF rats are the naturally occurring...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Genes, Recessive

Share to Genotype

Share to Microsatellite Repeats

Share to Obesity

Source

Identifiers

PMID: 9486157
DOI: 10.1152/ajpendo.1998.274.2.E265

Genes

CCKAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene.PMID 9486157Read ↗

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.Semantic proximity Read ↗

Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.Semantic proximity Read ↗

A diabetogenic gene, ODB2, identified on chromosome 14 of the OLETF rat and its synergistic action with ODB1.Semantic proximity Read ↗

Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat.Semantic proximity Read ↗

Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.Semantic proximity Read ↗

New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats.Semantic proximity Read ↗

Genetic analysis of non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.Semantic proximity Read ↗

Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats.Semantic proximity Read ↗

Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat.Semantic proximity Read ↗

Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.Semantic proximity Read ↗

A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.