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Article

A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene.

The American journal of physiology - 1 Feb 1998

Takiguchi S, Takata Y, Takahashi N, Kataoka K, Hirashima T, Kawano K, Miyasaka K, Funakoshi A, Kono A

Abstract excerpt

Otsuka Long-Evans Tokushima fatty (OLETF) rats develop hyperglycemia, hyperinsulinemia, and mild obesity, which are characteristic of human non-insulin-dependent diabetes mellitus. We have shown that two recessive genes, ODB1 mapped on the X chromosome and ODB2 mapped on chromosome 14, are involv...

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Source

Identifiers

PMID: 9486157
DOI: 10.1152/ajpendo.1998.274.2.E265

Genes

CCKAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9486157-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene.PMID 9486157Read ↗

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.Semantic proximity Read ↗

Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF x BN) x OLETF.Semantic proximity Read ↗

A diabetogenic gene, ODB2, identified on chromosome 14 of the OLETF rat and its synergistic action with ODB1.Semantic proximity Read ↗

Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat.Semantic proximity Read ↗

Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat.Semantic proximity Read ↗

New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats.Semantic proximity Read ↗

Genetic analysis of non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.Semantic proximity Read ↗

Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats.Semantic proximity Read ↗

Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat.Semantic proximity Read ↗

Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat.Semantic proximity Read ↗

A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat.Semantic proximity Read ↗

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