Article
Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation.
Current genetics - 1 Sept 1998
Gupta V, Kohli A, Krishnamurthy S, Puri N, Aalamgeer S A, Panwar S, Prasad R
Abstract excerpt
CaMDR1 (Candida albicans Multi Drug Resistance) encodes a major facilitator whose expression in Saccharomyces cerevisiae confers resistance to several unrelated drugs. We describe here the identification and molecular characterization of seven mutant alleles of CaMDR1 (CaMDR1-1 to 1-7). The complete sequencing of CaMDR1 alleles revealed several in-frame point mutations leading to a change in amino-acid residues...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.