Article
Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation.
Current genetics - 1 Sept 1998
Gupta V, Kohli A, Krishnamurthy S, Puri N, Aalamgeer S A, Panwar S, Prasad R
Abstract excerpt
CaMDR1 (Candida albicans Multi Drug Resistance) encodes a major facilitator whose expression in Saccharomyces cerevisiae confers resistance to several unrelated drugs. We describe here the identification and molecular characterization of seven mutant alleles of CaMDR1 (CaMDR1-1 to 1-7). The compl...
Topics
- Alleles
- Amino Acid Sequence
- Candida albicans
- Cloning, Molecular
- Drug Resistance, Multiple
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, MDR
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- RNA, Messenger
- Sequence Alignment
- Sequence Analysis, DNA