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Directed Mutational Strategies Reveal Drug Binding and Transport by the MDR Transporters of Candida albicans

20 Jan 2021

Abstract excerpt

Multidrug resistance (MDR) transporters belonging to either the ATP-Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) groups are major determinants of clinical drug resistance in fungi. The overproduction of these proteins enables the extrusion of incoming drugs at rates that prevent lethal effects. The promiscuity of these proteins is intriguing because they export a wide range of structurally...

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PMID: 33498218
DOI: 10.3390/jof7020068

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