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Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic <i>Candida albicans</i>

27 Apr 2011

Abstract excerpt

Reduced intracellular accumulation of drugs (due to rapid efflux) mediated by the efflux pump proteins belonging to ABC (ATP Binding Cassette) and MFS (Major Facilitators) superfamily is one of the most common strategies adopted by multidrug resistance (MDR) pathogenic yeasts. To combat MDR, it is essential to understand the structure and function of these transporters so that inhibitors/modulators to these can...

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PMID: 22312462
DOI: 10.4061/2011/531412

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