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Article

An MDR1 promoter allele with higher promoter activity is common in clinically isolated strains of Candida albicans.

Molecular genetics and genomics : MGG - 1 Dec 2011

Bruzual Igor, Kumamoto Carol A

Abstract excerpt

In the opportunistic fungal pathogen Candida albicans, up-regulation of MDR1, encoding an efflux transporter, leads to increased resistance to the antifungal drug fluconazole. Antifungal resistance has been linked to several types of genetic change in C. albicans, including changes in genome structure, genetic alteration of the drug target, and overexpression of transporters. High-level over-expression of MDR1 is...

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Identifiers

PMID: 21972105
DOI: 10.1007/s00438-011-0650-z
PMCID: PMC3874411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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