Article
The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1998
Freeman G J, Cardoso A A, Boussiotis V A, Anumanthan A, Groves R W, Kupper T S, Clark E A, Nadler L M
Abstract excerpt
The identification of all CD28/CTLA-4 counterreceptors is critical to our understanding of this pivotal pathway of T cell activation. Clouding our understanding has been the reported discrepancies in expression and function of the B7-1 (CD80) molecule based upon the use of the BB1 vs other anti-B...
Topics
- 3T3 Cells
- Abatacept
- Amino Acid Sequence
- Animals
- Antibodies, Blocking
- Antibodies, Monoclonal
- Antibody Specificity
- Antigens, CD
- Antigens, Differentiation
- Antigens, Differentiation, B-Lymphocyte
- B7-1 Antigen
- Binding Sites, Antibody
- CD28 Antigens