Article
Antibodies to B7.1 define the GFCC'C" face of the N-terminal domain as critical for co-stimulatory interactions.
Immunology letters - 2 Sept 2002
Wang Suyue, Veldman Geertruida M, Stahl Mark, Xing Yuzhe, Tobin James F, Erbe David V
Abstract excerpt
Antagonists of the B7 family of co-stimulatory molecules have the potential for altering immune responses therapeutically. To better define the requirements for such inhibitors, we have mapped the binding of an entire panel of blocking antibodies specific for human B7.1. By mutagenesis, each of the residues critical for blocking antibody binding appeared to fall entirely within the N-terminal V-set domain of...
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