Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

doi:10.1084/jem.177.4.925

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Article

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

The Journal of experimental medicine - 1 Apr 1993

Ranheim E A, Kipps T J

Abstract excerpt

Cognate interactions between antigen-presenting B and T cells play crucial roles in immunologic responses. T cells that have been activated via the crosslinking of CD3 are able to induce B cell proliferation and immunoglobulin secretion in a major histocompatibility complex-unrestricted and contact-dependent manner. We find that such activated human CD4+ T cells, but not control Ig-treated T cells, may induce...

Topics

Animals
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
Antigens, Surface
B-Lymphocytes
B7-1 Antigen
CD40 Antigens
Cell Adhesion Molecules
Cells, Cultured
Humans
Intercellular Adhesion Molecule-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Leukemia

Lymphocyte Activation

Mice

Phenotype

Signal Transduction

T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 7681471
DOI: 10.1084/jem.177.4.925
PMCID: PMC2190967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7681471-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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