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Article

The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells.

1 Mar 1991

Abstract excerpt

Activation via the T lymphocyte cell surface molecule CD28 provides a potent amplification signal for interleukin 2 (IL-2) production in several in vitro systems. The B lymphocyte activation antigen, B7/BB1, is a natural ligand for CD28. Here we investigate the role of CD28 and B7/BB1 in primary activation of CD4+ T lymphocytes stimulated with allogeneic B lymphoblastoid cell lines. A subset of peripheral CD4+ T...

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Identifiers

PMID: 1847724
DOI: 10.1084/jem.173.3.759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4+ T cells.PMID 1847724Read ↗

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.Semantic proximity Read ↗

B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells <i>in vitro</i>Semantic proximity Read ↗

CD80, CD86 and CD40 Provide Accessory Signals in a Multiple‐Step T‐Cell Activation ModelSemantic proximity Read ↗

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cellsSemantic proximity Read ↗

Studies Using Antigen-Presenting Cells Lacking Expression of Both B7-1 (CD80) and B7-2 (CD86) Show Distinct Requirements for B7 Molecules During Priming Versus Restimulation of Th2 But Not Th1 Cytokine ProductionSemantic proximity Read ↗

Regulation of Human B-Cell Activation and AdhesionSemantic proximity Read ↗

4-1BB Is Superior to CD28 Costimulation for Generating CD8+ Cytotoxic Lymphocytes for Adoptive ImmunotherapySemantic proximity Read ↗

The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor.Semantic proximity Read ↗

CD1+ thymocytes proliferate and give rise to functional cells after stimulation with monoclonal antibodies recognizing CD3, CD2 or CD28 surface molecules.Semantic proximity Read ↗

Coactivation with anti-CD28 monoclonal antibody enhances anti-CD3 monoclonal antibody-induced proliferation and IL-2 synthesis in T cells from autologous bone marrow transplant recipients.Semantic proximity Read ↗

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide.Semantic proximity Read ↗

Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice.Semantic proximity Read ↗

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