Article
Identification of conserved amino acids in murine B7-1IgV domain critical for CTLA4/CD28:B7 interaction by site-directed mutagenesis: a novel structural model of the binding site.
Molecular immunology - 1 Mar 1998
Guo Y, Wu Y, Kong X, Liu Y
Abstract excerpt
The B7: CD28/CTLA4 interaction plays a major role in T cell responses. Immune intervention targeted at this interaction has demonstrated a vast potential in enhancing tumor immunity and blocking autoimmunity and transplant rejection. However, the structural basis for this interaction is unclear....
Topics
- Abatacept
- Amino Acid Sequence
- Animals
- Antigens, CD
- Antigens, Differentiation
- B7-1 Antigen
- Binding Sites
- CD28 Antigens
- CD4-Positive T-Lymphocytes
- CTLA-4 Antigen
- Cell Line
- Conserved Sequence
- Epitopes
- Immunoconjugates
- Immunoglobulin Variable Region
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL