Article
The role of v-Fgr myristoylation and the Gag domain in membrane binding and cellular transformation.
Virology - 15 Sept 1998
Baker S J, Cosenza S C, Reddy E P
Abstract excerpt
The v-fgr oncogene encodes a chimeric oncoprotein composed of feline sarcoma virus (FeSV)-derived gag and cellular-derived actin and c-Fgr sequences. v-Fgr is myristoylated and membrane bound, two criteria which must be met for src kinases to induce cellular transformation. Although inhibition of...
Topics
- 3T3 Cells
- Animals
- Binding Sites
- Cats
- Cell Transformation, Viral
- Gene Products, gag
- Mice
- Mutation
- Protein Binding
- Protein-Tyrosine Kinases
- Retroviridae Proteins, Oncogenic
- Sarcoma Viruses, Feline