Article
Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein.
The Journal of general virology - 1 Mar 2006
Bentham Matthew, Mazaleyrat Sabine, Harris Mark
Abstract excerpt
Human immunodeficiency virus type 1 Nef protein is N-terminally myristoylated, a modification reported to be required for the association of Nef with cytoplasmic membranes. As myristate alone is not sufficient to anchor a protein stably into a membrane, it has been suggested that N-terminal basic residues contribute to Nef membrane association via electrostatic interactions with acidic phospholipids. Here, data...
Topics
- Amino Acid Sequence
- Arginine
- CD4 Antigens
- Cell Membrane
- Down-Regulation
- Gene Products, nef
- HIV-1
- HeLa Cells
- Humans
- Lysine
- Molecular Sequence Data
- Mutation
- Myristic Acid
- nef Gene Products, Human Immunodeficiency Virus