Article
p53 status in radiation-induced soft-tissue sarcomas.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] - 1 Aug 1998
Taubert H, Meye A, Bache M, Hinze R, Holzhausen H J, Schmidt H, Rath F W, Dunst J, Würl P
Abstract excerpt
BACKGROUND: Following therapeutic irradiation after a latency period of many years radiation-induced tumors, often sarcomas, can arise. Results of radiation-induced DNA damage can be 1. p53 over-expression, inducing growth arrest or apoptosis, and 2. occurrence of mutations, frequently including the p53 gene, as one molecular promotor for carcinogenesis. We were interested whether radiation-induced sarcomas are...
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