Article
Mutation of the p53 gene in postradiation sarcoma.
Laboratory investigation; a journal of technical methods and pathology - 1 Jun 1998
Nakanishi H, Tomita Y, Myoui A, Yoshikawa H, Sakai K, Kato Y, Ochi T, Aozasa K
Abstract excerpt
Radiotherapy is known to cause secondary malignancies in the radiation field; postradiation sarcomas (PRS) are one example of such malignancies. Little is known about the genetic changes, including p53 gene alterations, that are thought to play a role in the tumorigenesis of human PRS. In the pre...
Topics
- Adolescent
- Adult
- Aged
- Amino Acid Sequence
- Base Sequence
- Child
- Female
- Genes, p53
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasms, Radiation-Induced