Article
Fas and mutant estrogen receptor chimeric gene: a novel suicide vector for tamoxifen-inducible apoptosis.
Japanese journal of cancer research : Gann - 1 Jul 1998
Kodaira H, Kume A, Ogasawara Y, Urabe M, Kitano K, Kakizuka A, Ozawa K
Abstract excerpt
Several cancer gene therapy strategies involve suicide genes to kill the neoplasm, or to regulate effector cells such as lymphocytes. We have developed an inducible apoptosis system with a Fas-estrogen receptor fusion protein (MfasER) for rapid elimination of transduced cells. In the present stud...
Topics
- Animals
- Apoptosis
- DNA Fragmentation
- Dose-Response Relationship, Drug
- Estradiol
- Estrogen Antagonists
- Genetic Therapy
- Mice
- Mutation
- Receptors, Estrogen
- Recombinant Fusion Proteins
- Tamoxifen
- fas Receptor