Agonist antibody and Fas ligand mediate different sensitivity to death in the signaling pathways of Fas and cytoplasmic mutants.

doi:10.1002/eji.1830270510

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Article

Agonist antibody and Fas ligand mediate different sensitivity to death in the signaling pathways of Fas and cytoplasmic mutants.

European journal of immunology - 1 May 1997

Thilenius A R, Braun K, Russell J H

Abstract excerpt

We have produced three forms of human Fas: full-length Fas, Fas with a C-terminal deletion, and a chimera between extracellular Fas and the intracellular domain of the tumor necrosis factor receptor I p55 subunit. We transfected cell lines with these constructs to compare the relative capacity of...

Topics

Animals
Antibodies, Monoclonal
Antibody-Dependent Cell Cytotoxicity
Apoptosis
Biomarkers
Cytoplasm
Fas Ligand Protein
Humans
Ligands
Lymphoma, T-Cell
Membrane Glycoproteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Inbred C57BL

Mutation

Recombinant Fusion Proteins

Sequence Deletion

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 9174599
DOI: 10.1002/eji.1830270510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9174599-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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