Article
Fas receptor-mediated apoptosis: a clinical application?
The Journal of pathology - 1 Feb 2002
Timmer Tineke, de Vries Elisabeth G E, de Jong Steven
Abstract excerpt
Fas is a membrane protein belonging to the death receptor family. Cross-linking of Fas by its ligand, FasL, or agonistic anti-Fas antibodies, induces apoptosis of cells expressing Fas on the membrane by triggering a cascade of caspases. Since many different tumours express Fas on their membrane, targeting Fas-mediated apoptosis by anti-Fas antibodies may be a promising anticancer therapy. Unfortunately, not all...
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