Article
The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody.
International immunology - 1 Apr 1991
Hashimoto S, Ishii A, Yonehara S
Abstract excerpt
The cell lines KB8, 16, and 18 are KB cells which constitutively express adenovirus type 2 (Ad2) E1a, E1a plus E1b, and E1b genes, respectively. We show here that KB18 cells are completely resistant to cytolysis by tumor necrosis factor (TNF) or anti-Fas, although KB8 and KB or KB16 are highly an...
Topics
- Adenoviruses, Human
- Antibodies, Monoclonal
- Antigens, Surface
- Cell Line
- Cytotoxicity, Immunologic
- Humans
- Mutation
- Oncogenes
- RNA, Messenger
- Receptors, Immunologic
- Superoxide Dismutase
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha
- fas Receptor