Article
A new alternative splice variant of the mouse Fas antigen with a deletion in the N-terminal portion of the extracellular domain.
Life sciences - 1 Jan 1996
Nakajima T, Ichii S, Furuyama J, Tamaoki T, Hashimoto T
Abstract excerpt
The Fas antigen (Fas/APO-1/CD95) has been shown to induce apoptosis when bound to a monoclonal anti-Fas antibody or Fas ligands. Recently, a new soluble human Fas isoform which lacks the transmembrane domain due to alternative splicing has been isolated; however, no mouse Fas isoforms have been r...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- DNA Primers
- DNA, Complementary
- Exons
- Genetic Variation
- Humans
- Liver
- Mice
- Molecular Sequence Data
- Organ Specificity
- Polymerase Chain Reaction
- RNA, Messenger
- Sequence Deletion
- Spleen