Article
A new alternative splice variant of the mouse Fas antigen with a deletion in the N-terminal portion of the extracellular domain.
Life sciences - 1 Jan 1996
Nakajima T, Ichii S, Furuyama J, Tamaoki T, Hashimoto T
Abstract excerpt
The Fas antigen (Fas/APO-1/CD95) has been shown to induce apoptosis when bound to a monoclonal anti-Fas antibody or Fas ligands. Recently, a new soluble human Fas isoform which lacks the transmembrane domain due to alternative splicing has been isolated; however, no mouse Fas isoforms have been reported so far. Analysis of Fas transcripts by RT-PCR detected no Fas transcripts corresponding to the human soluble...
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