Defective death receptor signaling as a cause of tumor immune escape.

doi:10.1006/scbi.2001.0405

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Defective death receptor signaling as a cause of tumor immune escape.

Seminars in cancer biology - 1 Feb 2002

French Lars E, Tschopp Jürg

Abstract excerpt

Death receptors are a subgroup of TNF-receptor family members that can trigger caspase-8 activation and apoptosis upon interaction with their selective ligands. One of the death receptors, Fas (CD95) and its ligand is critically involved in the regulation of immune homeostasis and effectorfunction. Fas-mediated cell death is a major pathway of cytolytic T-cell-mediated death that is involved in specific killing...

Topics

Humans
Mutation
Neoplasms
Receptors, Tumor Necrosis Factor
Signal Transduction
fas Receptor

Source

Open in PubMed

Identifiers

PMID: 11926412
DOI: 10.1006/scbi.2001.0405

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics