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Article

Apoptosis in a Fas-resistant, T-cell receptor-sensitive human leukaemic T-cell clone.

Immunology - 1 Mar 1997

Delehanty L L, Payne J A, Farrow S N, Brown R, Champion B R

Abstract excerpt

The Fas (CD95) antigen plays a key role in regulating T-cell activation and survival. We have generated a Fas-resistant subclone of the human T-cell leukaemia line, H9, which is still able to undergo apoptosis in response to T-cell receptor ligation. Molecular analyses revealed that resistance to Fas-mediated apoptosis was due to a heterozygous mutation in the death domain of the Fas gene which generates a stop...

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Identifiers

PMID: 9155645
DOI: 10.1111/j.1365-2567.1997.00383.x
PMCID: PMC1456596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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