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Article

Identification of functional genes during Fas-mediated apoptosis using a randomly fragmented cDNA library.

Cellular and molecular life sciences : CMLS - 1 Sept 2005

Hassan M, Mirmohammadsadegh A, Selimovic D, Nambiar S, Tannapfel A, Hengge U R

Abstract excerpt

We describe a general strategy for the identification of functional genes that, when downregulated, result in a selectable phenotype. This strategy is based on expression selection of cDNA fragments that counteract their cognate genes. A cDNA library containing random fragments expressed in human HepG2, A375 and CLS-354 cells was used to identify functional genes whose inhibition conferred resistance to...

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Identifiers

PMID: 16091844
DOI: 10.1007/s00018-005-5172-6
PMCID: PMC11139157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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