Article
The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression.
The Journal of biological chemistry - 25 Sept 1998
Yu X, Wu L C, Bowcock A M, Aronheim A, Baer R
Abstract excerpt
The BRCA1 tumor suppressor encodes a polypeptide with two recognizable protein motifs: a RING domain near the N terminus and two tandem BRCT domains at the C terminus. Studies of tumor-associated mutations indicate that the RING and BRCT sequences are required for BRCA1-mediated tumor suppression...
Topics
- Alcohol Oxidoreductases
- BRCA1 Protein
- Cell Line
- DNA-Binding Proteins
- Humans
- Mutation
- Phosphoproteins
- Protein Binding
- Transcription, Genetic