Article
Mutations in the BRCT domain confer temperature sensitivity to BRCA1 in transcription activation.
Cancer biology & therapy - 1 Jan 2000
Carvalho Marcelo A, Billack Blase, Chan Emily, Worley Terri, Cayanan Charmagne, Monteiro Alvaro N A
Abstract excerpt
BRCA1 is a tumor suppressor gene and germ line mutations account for the majority of familial cases of breast and ovarian cancer. There is mounting evidence that BRCA1 functions in DNA repair and transcriptional regulation. A major hurdle to dissect the role of BRCA1 is the lack of molecular reagents to carry out biochemical and genetic experiments. Therefore, we used random mutagenesis of the C-terminus of BRCA1...
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