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Article

Cancer predisposing mutations in BRCT domains.

IUBMB life - 1 Jul 2011

di Masi Alessandra, Gullotta Francesca, Cappadonna Valentina, Leboffe Loris, Ascenzi Paolo

Abstract excerpt

Members of the breast cancer 1 (BRCA1) carboxy-terminal (BRCT) superfamily are involved in the cellular response to the DNA damage sensing and repair, as well as in the cell cycle control. All proteins are characterized by one or more BRCT domain(s), which provides a flexible framework representing scaffolding element(s) in multi-protein complexes. In particular, BRCA1, nibrin (NBN), and microcephalin (MCPH1),...

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Identifiers

PMID: 21698754
DOI: 10.1002/iub.472

Genes

BRCA1
MCPH1
NBN

Provenance

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