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Article

The BRCT domain is a phospho-protein binding domain.

Science (New York, N.Y.) - 24 Oct 2003

Yu Xiaochun, Chini Claudia Christiano Silva, He Miao, Mer Georges, Chen Junjie

Abstract excerpt

The carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein is an evolutionarily conserved module that exists in a large number of proteins from prokaryotes to eukaryotes. Although most BRCT domain-containing proteins participate in DNA-damage checkpoint or DNA-repair pathways, or both, the function of the BRCT domain is not fully understood. We show that the BRCA1 BRCT domain directly...

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Source

Identifiers

PMID: 14576433
DOI: 10.1126/science.1088753

Genes

BRCA1
BACH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The BRCT domain is a phospho-protein binding domain.PMID 14576433Read ↗

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Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.Semantic proximity Read ↗

Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.Semantic proximity Read ↗

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligandsSemantic proximity Read ↗

Structure of an XRCC1 BRCT domain: a new protein-protein interaction module.Semantic proximity Read ↗

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteinsSemantic proximity Read ↗

Cancer predisposing mutations in BRCT domains.Semantic proximity Read ↗

A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell SurvivalSemantic proximity Read ↗

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Semantic proximity Read ↗

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Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.Semantic proximity Read ↗

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