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Article

The DNA resection protein CtIP promotes mammary tumorigenesis.

Oncotarget - 31 May 2016

Reczek Colleen R, Shakya Reena, Miteva Yana, Szabolcs Matthias, Ludwig Thomas, Baer Richard

Abstract excerpt

Many DNA repair factors act to suppress tumor formation by preserving genomic stability. Similarly, the CtIP protein, which interacts with the BRCA1 tumor suppressor, is also thought to have tumor suppression activity. Through its role in DNA end resection, CtIP facilitates DNA double-strand break (DSB) repair by homologous recombination (DSBR-HR) and microhomology-mediated end joining (MMEJ). In addition,...

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Share to DNA End-Joining Repair
Share to Genomic Instability
Share to Mammary Glands, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Experimental

Share to Mice, 129 Strain

Share to Milk Proteins

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Share to Recombinational DNA Repair

Source

Open in PubMed Open full text

Identifiers

PMID: 27058754
DOI: 10.18632/oncotarget.8605
PMCID: PMC5078005

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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The DNA resection protein CtIP promotes mammary tumorigenesis.PMID 27058754Read ↗

Human CtIP: A ‘double agent’ in DNA repair and tumorigenesisSemantic proximity Read ↗

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.Semantic proximity Read ↗

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.Semantic proximity Read ↗

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.Semantic proximity Read ↗

Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stabilitySemantic proximity Read ↗

BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damageSemantic proximity Read ↗

Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitorsSemantic proximity Read ↗

Human CtIP promotes DNA end resectionSemantic proximity Read ↗

Inactivation of CtIP Leads to Early Embryonic Lethality Mediated by G1 Restraint and to Tumorigenesis by Haploid InsufficiencySemantic proximity Read ↗

DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.Semantic proximity Read ↗

The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression.Semantic proximity Read ↗

The PIN1–p38–CtIP signalling axis protects stalled replication forks from deleterious degradationSemantic proximity Read ↗

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