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Article

Impact of RING and BRCT domain mutations on BRCA1 protein stability, localization and recruitment to DNA damage.

Radiation research - 1 Jul 2010

Nelson Andrew C, Holt Jeffrey T

Abstract excerpt

Mutations within the tumor suppressor BRCA1 cause the majority of hereditary breast and ovarian cancers. The BRCA1 protein is an important regulator of DNA double-strand break repair, and BRCA1-deficient cells are highly sensitive to ionizing radiation. Furthermore, BRCA1 function may contribute to enforcement of the G(2) cell cycle checkpoint. E3-ubiquitin ligase activity is the only known enzymatic activity of...

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Topics

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Share to BRCA1 Protein
Share to Breast Neoplasms
Share to Carcinoma, Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Cell Nucleus

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Share to BARD1 gene

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Source

Open in PubMed Open full text

Identifiers

PMID: 20681793
DOI: 10.1667/RR1290.1
PMCID: PMC4550207

Genes

BRCA1
BACH1
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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