Article
A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs.
Molecular cell - 1 Aug 1998
Coquelle A, Toledo F, Stern S, Bieth A, Debatisse M
Abstract excerpt
Genome rearrangements including gene amplification are frequent properties of tumor cells, but how they are related to the tumor microenvironment is unknown. Here, we report direct evidence for a causal relationship between hypoxia, induction of fragile sites, and gene amplification. Recently, we...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Cell Hypoxia
- Cell Line
- Chromosome Breakage
- Chromosome Fragile Sites
- Chromosome Fragility
- Cricetinae
- Cricetulus
- Drug Resistance, Multiple
- Extrachromosomal Inheritance
- Gene Amplification
- Gene Rearrangement
- Humans
- Hypoxia
- In Situ Hybridization, Fluorescence
- Models, Biological
- Mutation