Article
The tumor microenvironment and DNA repair.
Seminars in radiation oncology - 1 Oct 2010
Klein Thomas J, Glazer Peter M
Abstract excerpt
Genetic instability is one of the hallmarks of cancer cells. As tumors grow, they progressively acquire mutations that ultimately allow them to invade normal tissues and metastasize to distant sites. This increased propensity for mutation also leads to cancers that are resistant to therapeutic intervention. Recent evidence has shown that the tumor microenvironment plays a major role in the etiology of this...
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