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Article

Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells.

International journal of cancer - 15 Mar 2014

Ji Wei, Bian Zehua, Yu Yang, Yuan Chao, Liu Yang, Yu Lisa, Li Chunxiang, Zhu Jing, Jia Xueyuan, Guan Rongwei, Zhang Chunyu, Meng Xiangning, Jin Yan, Bai Jing, Yu Jingcui, Lee Ki-Young, Sun Wenjing, Fu Songbin

Abstract excerpt

Double minute chromosomes (DMs) are a hallmark of gene amplification. The relationship between the formation of DMs and the amplification of DM-carried genes remains to be clarified. The human colorectal cancer cell line NCI-H716 and human malignant primitive neuroectodermal tumor cell line SK-PN-DW are known to contain many DMs. To examine the amplification of DM-carried genes in tumor cells, we performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24027017
DOI: 10.1002/ijc.28467
PMCID: PMC4233979

Genes

FGFR2
MTSS1
MYC
NDUFB9
NSMCE2
TRIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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