Among B-type cyclins only CLB5 and CLB6 promote premeiotic S phase in Saccharomyces cerevisiae.

doi:10.1534/genetics.111.134684

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Article

Among B-type cyclins only CLB5 and CLB6 promote premeiotic S phase in Saccharomyces cerevisiae.

Genetics - 1 Mar 2012

DeCesare James M, Stuart David T

Abstract excerpt

The Saccharomyces cerevisiae cyclin Clb5 is required for premeiotic S phase, meiotic recombination, and successful progression through meiosis. Clb5 is not essential for mitotic proliferation because Clb1-Clb4 can support DNA replication in clb5 clb6 mutants. Clb1, Clb3, and Clb4 accumulate in clb5 clb6 cells during meiotic differentiation yet fail to promote premeiotic DNA replication. When expressed under the...

Topics

Cyclin B
DNA Replication
Genomic Instability
Meiosis
Mutant Chimeric Proteins
Mutation
Promoter Regions, Genetic
Protein Kinases
S Phase
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 22209902
DOI: 10.1534/genetics.111.134684
PMCID: PMC3296238

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