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Article

CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint.

Genes & development - 1 Sept 1998

Stuart D, Wittenberg C

Abstract excerpt

Initiation of DNA replication during the mitotic cell cycle requires the activation of a cyclin-dependent protein kinase (CDK). The B-type cyclins Clb5 and Clb6 are the primary activators of the S phase function of the budding yeast CDK Cdc28. However, in mitotically growing cells this role can be fulfilled by the other B-type cyclins Clb1-Clb4. We report here that cells undergoing meiotic development also...

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PMID: 9732268
DOI: 10.1101/gad.12.17.2698
PMCID: PMC317137

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Research trail→

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CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint.PMID 9732268Read ↗

Among B-type cyclins only CLB5 and CLB6 promote premeiotic S phase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Diminished S-phase cyclin-dependent kinase function elicits vital Rad53-dependent checkpoint responses in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast mitotic cyclin Clb2 cannot substitute for S phase cyclins in replication origin firing.Semantic proximity Read ↗

Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.Semantic proximity Read ↗

CLB5-dependent activation of late replication origins in S. cerevisiae.Semantic proximity Read ↗

PP2A (Cdc)⁵⁵ is required for multiple events during meiosis I.Semantic proximity Read ↗

Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p is required for efficient induction and execution of meiotic development.Semantic proximity Read ↗

Regulation of meiotic S phase by Ime2 and a Clb5,6-associated kinase in Saccharomyces cerevisiae.Semantic proximity Read ↗

The B-type cyclin Clb4 prevents meiosis I sister centromere separation in budding yeast.Semantic proximity Read ↗

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.Semantic proximity Read ↗

Cdc28 and Ime2 possess redundant functions in promoting entry into premeiotic DNA replication in Saccharomyces cerevisiae.Semantic proximity Read ↗

Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae.Semantic proximity Read ↗

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