CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint.

doi:10.1101/gad.12.17.2698

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Article

CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint.

Genes & development - 1 Sept 1998

Stuart D, Wittenberg C

Abstract excerpt

Initiation of DNA replication during the mitotic cell cycle requires the activation of a cyclin-dependent protein kinase (CDK). The B-type cyclins Clb5 and Clb6 are the primary activators of the S phase function of the budding yeast CDK Cdc28. However, in mitotically growing cells this role can b...

Topics

Cell Cycle
Cyclin B
Cyclins
DNA Replication
Fungal Proteins
Gamma Rays
Genotype
Meiosis
Mitosis
Mutagenesis
Mutagenesis, Site-Directed
Recombinant Proteins
S Phase
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Spores, Fungal

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