Article
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
Immunity - 1 Aug 1998
Varfolomeev E E, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann J S, Mett I L, Rebrikov D, Brodianski V M, Kemper O C, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham K B, Goncharov T, Holtmann H, Lonai P, Wallach D
Abstract excerpt
Homozygous targeted disruption of the mouse Caspase 8 (Casp8) gene was found to be lethal in utero. The Caspase 8 null embryos exhibited impaired heart muscle development and congested accumulation of erythrocytes. Recovery of hematopoietic colony-forming cells from the embryos was very low. In f...
Topics
- Animals
- Caspase 8
- Caspase 9
- Caspases
- Cell Death
- Cells, Cultured
- Cysteine Endopeptidases
- DNA, Complementary
- Fetal Death
- Fibroblasts
- Gene Targeting
- Genes, Lethal
- Gestational Age
- Mice