Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder.

International immunology - 1 Feb 1998

Kasahara Y, Wada T, Niida Y, Yachie A, Seki H, Ishida Y, Sakai T, Koizumi F, Koizumi S, Miyawaki T, Taniguchi N

Abstract excerpt

Fas is an apoptosis-signaling receptor important for homeostasis of the immune system. In this study, Fas-mediated apoptosis and Fas mutations were analyzed in three Japanese children from two families with a lymphoproliferative disorder characterized by lymphadenopathy, hepatosplenomegaly, pancytopenia, hypergammaglobulinemia and an increase in TCR alphabeta+ CD4- CD8- T cells. Apoptosis induced by anti-Fas mAb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Child, Preschool
Share to Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn

Share to Lymphocyte Activation

Share to Lymphoproliferative Disorders

Share to Membrane Glycoproteins

Share to Mutation

Source

Identifiers

PMID: 9533447
DOI: 10.1093/intimm/10.2.195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Fas (CD95/APO-1) mutations in infants with a lymphoproliferative disorder.PMID 9533447Read ↗

Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.Semantic proximity Read ↗

Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological AnalysisSemantic proximity Read ↗

Clinical, Immunologic, and Genetic Features of an Autoimmune Lymphoproliferative Syndrome Associated With Abnormal Lymphocyte ApoptosisSemantic proximity Read ↗

Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations.Semantic proximity Read ↗

CD95 (APO-1/FAS) deficiency in infant acute lymphoblastic leukemia: detection of novel soluble Fas splice variants.Semantic proximity Read ↗

Clinical, immunological, and pathological consequences of Fas-deficient conditions.Semantic proximity Read ↗

The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis.Semantic proximity Read ↗

ALPS: an autoimmune human lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.Semantic proximity Read ↗

A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndromeSemantic proximity Read ↗

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosisSemantic proximity Read ↗

Immunologic evaluation and genetic defects of apoptosis in patients with autoimmune lymphoproliferative syndrome (ALPS).Semantic proximity Read ↗

In utero and early postnatal presentation of autoimmune lymphoproliferative syndrome in a family with a novel FAS mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.