Article
Defects in regulation of apoptosis in caspase-2-deficient mice.
Genes & development - 1 May 1998
Bergeron L, Perez G I, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham K E, Flaws J A, Salter J C, Hara H, Moskowitz M A, Li E, Greenberg A, Tilly J L, Yuan J
Abstract excerpt
During embryonic development, a large number of cells die naturally to shape the new organism. Members of the caspase family of proteases are essential intracellular death effectors. Herein, we generated caspase-2-deficient mice to evaluate the requirement for this enzyme in various paradigms of apoptosis. Excess numbers of germ cells were endowed in ovaries of mutant mice and the oocytes were found to be...
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