Article
Critical test of hot spot motifs for immunoglobulin hypermutation.
European journal of immunology - 1 Dec 1997
Bachl J, Steinberg C, Wabl M
Abstract excerpt
In hypermutation at the immunoglobulin loci, some bases are much more mutable than others. The increased mutability of the hot spots has been attributed to their being embedded in short sequence motifs. Among the suggested motifs are palindromes, TAA and RGYW (i.e. A/G G C/T A/T). We have tested...
Topics
- Animals
- Genes, Immunoglobulin
- Humans
- Immunoglobulins
- Mutation