Article
Transcription, beta-like DNA polymerases and hypermutation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001
Reynaud C A, Frey S, Aoufouchi S, Faili A, Bertocci B, Dahan A, Flatter E, Delbos F, Storck S, Zober C, Weill J C
Abstract excerpt
This paper discusses two aspects of immunoglobulin (Ig) gene hypermutation. In the first approach, a transcription termination signal is introduced in an Ig light chain transgene acting as a mutation substrate, and transgenic lines are generated with control and mutant transgenes integrated in tandem. Analysis of transcription levels and mutation frequencies between mutant and control transgenes clearly...
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