Article
DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes.
The Journal of experimental medicine - 22 Aug 2016
Maul Robert W, MacCarthy Thomas, Frank Ekaterina G, Donigan Katherine A, McLenigan Mary P, Yang William, Saribasak Huseyin, Huston Donald E, Lange Sabine S, Woodgate Roger, Gearhart Patricia J
Abstract excerpt
DNA polymerase ι (Pol ι) is an attractive candidate for somatic hypermutation in antibody genes because of its low fidelity. To identify a role for Pol ι, we analyzed mutations in two strains of mice with deficiencies in the enzyme: 129 mice with negligible expression of truncated Pol ι, and knock-in mice that express full-length Pol ι that is catalytically inactive. Both strains had normal frequencies and...
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