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Article

Timing matters: error-prone gap filling and translesion synthesis in immunoglobulin gene hypermutation.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Mar 2009

Sale Julian E, Batters Christopher, Edmunds Charlotte E, Phillips Lara G, Simpson Laura J, Szüts Dávid

Abstract excerpt

By temporarily deferring the repair of DNA lesions encountered during replication, the bypass of DNA damage is critical to the ability of cells to withstand genomic insults. Damage bypass can be achieved either by recombinational mechanisms that are generally accurate or by a process called translesion synthesis. Translesion synthesis involves replacing the stalled replicative polymerase with one of a number of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19008194
DOI: 10.1098/rstb.2008.0197
PMCID: PMC2660919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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